No, none of the COVID-19 vaccines have any effect on or interaction with your DNA. mRNA vaccines instruct cells on how to produce a protein that stimulates an immune response within the body. Antibodies are produced as a result of this response, which keep you safe from the pathogen. mRNA differs from DNA in that it only lasts 72 hours inside the cell before decaying. It never makes it into the nucleus of the cell, where DNA is stored.